Dr. Thon

Instructor, Harvard Medical School


The Black Hole: Issues of Interest to Early-Career Scientists in Canada

A Biweekly Columnist, view all of my posts online or via RSS

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The Black Hole: Science in Canada / Issues Affecting Trainees

The original home of the Black Hole; view the archive of my first posts online or via RSS

Soapbox Science: Community Guest Blog from Nature.com

Speaking Up in Support of Federally Funded Research

Factual Footage Inc.

Factual Footage Inc. is a science consulting firm that specializes in the film & television industries.
Its mission is to ensure the authenticity of science in the arts while upholding creative vision

FFI consults on all forms of media: film, television, theatre, video games, novels & others

FFI consults on all disciplines of science: biology, chemistry, biochemistry, genetics, physics, medical science

Some of the ways they can help:

  • fact-checking of scripts and props (pre- and post-production)
  • draft scientifically conceivable details to support your creative vision
  • answer any science-related questions

Platelet BioGenesis Inc.

Platelet BioGenesis is a biotechnology company that is developing a microfluidic-based bioreactor which mimics human bone marrow to produce human platelets.

Episode # 2 – Jonathan Thon – See something that no one ever sees – Feb 12, 2015

Feb 12, 2015 Their research focuses on how blood platelets, which function as the band-aids of the bloodstream, are produced from megakaryocyte precursor cells. He’s now taking his team to new levels by bringing their work to the clinical and commercial world. He shares his entrepreneurial journey with other academic researchers who have similar interest in bringing their own science to the business world.

Platelet Production, Pumped Up – Jan-Feb, 2015

Jan-Feb, 2015 Discover Magazine’s Top 100 Inventions of 2014 – #26. “Bioreactor on a chip” could help meet rising demand for blood transfusions.

Scientists Successfully Generate Human Platelets Using Next-Generation Bioreactor – July 22, 2014

July 22, 2014 Scientists at Brigham and Women’s Hospital (BWH) have developed a scalable, next-generation platelet bioreactor to generate fully functional human platelets in vitro. The work is a major biomedical advancement that will help address blood transfusion needs worldwide.

Boston researchers make breakthrough on platelet production
NECN (Dr. Jonathan Thon featured in a LIVE interview with Bridget Blythe at New England Channel News)

Thon Selected as First Recipient of Boston Biomedical Innovation Center DRIVE Grant – July 2, 2014

July 2, 2014 With the award, approximately $350,000, Thon hopes to produce a next-generation bioreactor to generate the world’s first donor-independent human platelets. The work is expected to scale platelet production to meet global transfusion needs and support drug development by modeling human bone marrow.

Biochip mimics how the body produces platelets so they could be made in a lab – April 21, 2014

April 21, 2014 When you hear about blood shortages, that doesn’t just mean there’s a shortage of donated red blood cells. It could also mean platelets, a blood component that Sven Karlsson described as Band-Aids of the bloodstream, because they’re necessary for blood clot formation to help stop bleeding. Karlsson is a co-founder and chief financial officer of Platelet BioGenesis, a Boston startup that’s developing a way to produce human platelets in a lab using a microfluidic-based bioreactor.

The platelet whisperers – March 27, 2014

March 27, 2014 One way of boosting platelet production in the lab is with a microfluidic bioreactor that mimics the physical characteristics of megakaryocytes’ bone marrow environment. Unlike traditional static culture methods for growing megakaryocytes, a platelet bioreactor is built to be structurally similar to bone marrow and exposes the cells to the same shear forces they experience within the real bone marrow environment. It also can act as a platform for studying physical and biochemical influences on platelet production.

RCSI Human Disease Mapping conference (HDM) – Keynote Address from Dr Jonathan Thon – January 30, 2014

January 30, 2014 Dr. Jonathan Thon, a leading researcher in therapies for cardiovascular diseases from Brigham and Women’s Hospital and Harvard Medical School delivers the second keynote address entitled ‘An Impactful Scientific Career’ at the RCSI Human Disease Mapping conference (HDM) which was held from 30th-31st January 2014.

Mimicking Milieus to Produce Platelets… for Science and Transfusion – March 5, 2012

March 5, 2012 Solving the platelet production problem: A microfluidic device that could reproduce the platelet’s developmental milieu in a way that serves both researchers wanting to understand platelet development and the patients in need of lifesaving platelet transfusions.

January February Hematologist 2012 PDF

Members of ash participate in inaugural advocacy leadership institute.

2011 ASH Advocacy Leadership Institute

October 12-13, 2011 The American Society of Hematology (ASH) Government Relations, Practice, and Scientific Affairs department two-day political advocacy program.

ASH Announces 2011 Scholar Award Winners

December 20, 2010 The American Society of Hematology (ASH) announces the 2011 Scholar Award recipients. The program is designed to support hematologists who have chosen a career in research by providing partial salary or other support during the critical period required for completion of training and achievement of status as an independent investigator.

2013 Gordon Research Seminar: Cell Biology of Megakaryocytes and Platelets

March 9-10, 2013 The Gordon Research Seminar on Cell Biology of Megakaryocytes and Platelets is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to bring together young investigators to present their latest innovative work toward advancing our understanding of megakaryocyte and platelet formation and function. Through career oriented presentations and round table discussion with both academic and pharmaceutical leaders in their field, this GRS will also provide young investigators with valuable career advice from experts conducting basic, translational and pharmaceutical research.

Look Who’s Talking – Clinical & Research News – June 3, 2013

June 3, 2013 Brigham and Women’s Hospital Profile.

Crowdfunding Academic Research – June 10, 2013

June 10, 2013 Democratizing research through crowdfunding as a way to complement federal/private grants for funding basic research.